T Lymphocyte Potential Marks the Emergence of Definitive Hematopoietic Progenitors in Human Pluripotent Stem Cell Differentiation Cultures

The efficient generation of hematopoietic stem cells from human pluripotent stem cells is dependent on the appropriate specification of the definitive hematopoietic program during differentiation. In this study, we used T lymphocyte potential to track the onset of definitive hematopoiesis from human...

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Bibliographic Details
Main Authors: Marion Kennedy, Geneve Awong, Christopher M. Sturgeon, Andrea Ditadi, Ross LaMotte-Mohs, Juan Carlos Zúñiga-Pflücker, Gordon Keller
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712003841