Emergence of a mutation in the nucleocapsid gene of SARS-CoV-2 interferes with PCR detection in Canada

Abstract The emergence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) was met with rapid development of robust molecular-based detection assays. Many SARS-CoV-2 molecular tests target multiple genetic regions of the virus to maximize detection and protect against diagnostic escape. De...

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Bibliographic Details
Main Authors: Sandra Isabel, Mariana Abdulnoor, Karel Boissinot, Marc R. Isabel, Richard de Borja, Philip C. Zuzarte, Calvin P. Sjaarda, Kevin R. Barker, Prameet M. Sheth, Larissa M. Matukas, Jonathan B. Gubbay, Alisson J. McGeer, Samira Mubareka, Jared T. Simpson, Ramzi Fattouh
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-13995-4