COX-2 Is Downregulated in Human Stenotic Aortic Valves and Its Inhibition Promotes Dystrophic Calcification

COX-2 Is Downregulated in Human Stenotic Aortic Valves and Its Inhibition Promotes Dystrophic Calcification

Calcific aortic valve disease (CAVD) is the result of maladaptive fibrocalcific processes leading to a progressive thickening and stiffening of aortic valve (AV) leaflets. CAVD is the most common cause of aortic stenosis (AS). At present, there is no effective pharmacotherapy in reducing CAVD progre...

Full description

Bibliographic Details
Main Authors: Francesco Vieceli Dalla Sega, Francesca Fortini, Paolo Cimaglia, Luisa Marracino, Elisabetta Tonet, Antonio Antonucci, Marco Moscarelli, Gianluca Campo, Paola Rizzo, Roberto Ferrari
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
CAVD (calcific aortic valve disease)
AS (aortic stenosis)
COX-2 (cyclooxygenase-2)
AVICs (aortic valve interstitial cells)
celecoxib
calcific nodules
Online Access:https://www.mdpi.com/1422-0067/21/23/8917

Internet

https://www.mdpi.com/1422-0067/21/23/8917

Similar Items