COX-2 Is Downregulated in Human Stenotic Aortic Valves and Its Inhibition Promotes Dystrophic Calcification

COX-2 Is Downregulated in Human Stenotic Aortic Valves and Its Inhibition Promotes Dystrophic Calcification

Calcific aortic valve disease (CAVD) is the result of maladaptive fibrocalcific processes leading to a progressive thickening and stiffening of aortic valve (AV) leaflets. CAVD is the most common cause of aortic stenosis (AS). At present, there is no effective pharmacotherapy in reducing CAVD progre...

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Bibliographic Details
Main Authors: Francesco Vieceli Dalla Sega, Francesca Fortini, Paolo Cimaglia, Luisa Marracino, Elisabetta Tonet, Antonio Antonucci, Marco Moscarelli, Gianluca Campo, Paola Rizzo, Roberto Ferrari
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
CAVD (calcific aortic valve disease)
AS (aortic stenosis)
COX-2 (cyclooxygenase-2)
AVICs (aortic valve interstitial cells)
celecoxib
calcific nodules
Online Access:https://www.mdpi.com/1422-0067/21/23/8917

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