Methotrexate-Induced Alteration of Renal Aquaporins 1 and 2, Oxidative Stress and Tubular Apoptosis Can Be Attenuated by Omega-3 Fatty Acids Supplementation

Methotrexate-Induced Alteration of Renal Aquaporins 1 and 2, Oxidative Stress and Tubular Apoptosis Can Be Attenuated by Omega-3 Fatty Acids Supplementation

Methotrexate (MTX) is a potent anti-cancer drug, commonly associated with nephrotoxicity via the induction of oxidative stress and apoptosis with alteration of renal water channel proteins, namely aquaporins (AQPs). Omega-3 long-chain polyunsaturated fatty acids (LC-PUFA) have shown cytoprotective e...

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Bibliographic Details
Main Authors: Mosaab Salah El-din El-Agawy, Alaa Mohamed Mohamed Badawy, Mohammed R. Rabei, Mohamed Mahmoud Abdelraheem Elshaer, Eman Mohamad El Nashar, Mansour A. Alghamdi, Mohammed A. Alshehri, Hassan Reda Hassan Elsayed
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
methotrexate
kidney
omega-3 fatty acids
apoptosis
aquaporins
oxidative stress
Online Access:https://www.mdpi.com/1422-0067/23/21/12794

Internet

https://www.mdpi.com/1422-0067/23/21/12794

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