Plasma Metabolome Normalization in Rheumatoid Arthritis Following Initiation of Methotrexate and the Identification of Metabolic Biomarkers of Efficacy

Methotrexate (MTX) efficacy in the treatment of rheumatoid arthritis (RA) is variable and unpredictable, resulting in a need to identify biomarkers to guide drug therapy. This study evaluates changes in the plasma metabolome associated with response to MTX in RA with the goal of understanding the me...

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Bibliographic Details
Main Authors: Matthew R. Medcalf, Pooja Bhadbhade, Ted R. Mikuls, James R. O’Dell, Rebekah L. Gundry, Ryan S. Funk
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Metabolites
Subjects:
Online Access:https://www.mdpi.com/2218-1989/11/12/824