MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer

Summary: We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics data and developed a biocomputational platform to construct a mathemati...

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Main Authors: ManSai Acón, Carsten Geiß, Jorge Torres-Calvo, Diana Bravo-Estupiñan, Guillermo Oviedo, Jorge L. Arias-Arias, Luis A. Rojas-Matey, Baez Edwin, Gloriana Vásquez-Vargas, Yendry Oses-Vargas, José Guevara-Coto, Andrés Segura-Castillo, Francisco Siles-Canales, Steve Quirós-Barrantes, Anne Régnier-Vigouroux, Pedro Mendes, Rodrigo Mora-Rodríguez
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:iScience
Subjects:
Bioinformatics
Mathematical biosciences
Systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422101378X

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http://www.sciencedirect.com/science/article/pii/S258900422101378X

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