PI3K/AKT/mTOR pathway, hypoxia, and glucose metabolism: Potential targets to overcome radioresistance in small cell lung cancer

PI3K/AKT/mTOR pathway, hypoxia, and glucose metabolism: Potential targets to overcome radioresistance in small cell lung cancer

Small cell lung cancer (SCLC) is a highly aggressive tumor type for which limited therapeutic progress has been made. Platinum-based chemotherapy with or without thoracic radiotherapy remains the backbone of treatment, but most patients with SCLC acquire therapeutic resistance. Given the need for mo...

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Bibliographic Details
Main Authors: Huan Deng, Yamei Chen, Peijing Li, Qingqing Hang, Peng Zhang, Ying Jin, Ming Chen
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cancer Pathogenesis and Therapy
Subjects:
Small cell lung cancer
PI3K/AKT/mTOR pathway
Glucose metabolism
Radioresistance
Online Access:http://www.sciencedirect.com/science/article/pii/S2949713222000015

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http://www.sciencedirect.com/science/article/pii/S2949713222000015

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