ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

Abstract Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing survival. The development of brain metastases is particularly harmful in triple-negative bre...

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Bibliographic Details
Main Authors: Julien Cicero, Sarah Trouvilliez, Martine Palma, Gaetan Ternier, Laurine Decoster, Eloise Happernegg, Nicolas Barois, Alexandre Van Outryve, Lucie Dehouck, Roland P. Bourette, Eric Adriaenssens, Chann Lagadec, Cagatay Mehmet Tarhan, Dominique Collard, Zied Souguir, Elodie Vandenhaute, Grégory Maubon, François Sipieter, Nicolas Borghi, Fumitaka Shimizu, Takashi Kanda, Paolo Giacobini, Fabien Gosselet, Nathalie Maubon, Xuefen Le Bourhis, Isabelle Van Seuningen, Caroline Mysiorek, Robert-Alain Toillon
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Experimental Hematology & Oncology
Subjects:
proNGF
TrkA
EphA2
Src
Brain metastasis
Breast cancer
Online Access:https://doi.org/10.1186/s40164-023-00463-6

Internet

https://doi.org/10.1186/s40164-023-00463-6

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