Decoding the spatial chromatin organization and dynamic epigenetic landscapes of macrophage cells during differentiation and immune activation

Decoding the spatial chromatin organization and dynamic epigenetic landscapes of macrophage cells during differentiation and immune activation

Here the authors delineate the dynamic changes in 3D genome and epigenome of differentiating macrophages and during infection with Mycobacterium tuberculosis. They reveal a role for NF-κB upon infection and identify SNPs in disease-susceptible loci, including rs1873613 that is located in the anchor...

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Bibliographic Details
Main Authors: Da Lin, Weize Xu, Ping Hong, Chengchao Wu, Zhihui Zhang, Siheng Zhang, Lingyu Xing, Bing Yang, Wei Zhou, Qin Xiao, Jinyue Wang, Cong Wang, Yu He, Xi Chen, Xiaojian Cao, Jiangwei Man, Aikebaier Reheman, Xiaofeng Wu, Xingjie Hao, Zhe Hu, Chunli Chen, Zimeng Cao, Rong Yin, Zhen F. Fu, Rong Zhou, Zhaowei Teng, Guoliang Li, Gang Cao
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33558-5

Internet

https://doi.org/10.1038/s41467-022-33558-5

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