Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking

Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking

Abstract Background Lymphocytes circulate between peripheral lymphoid tissues via blood and lymphatic systems, and chemokine-induced migration is important in trafficking lymphocytes to distant sites. The small GTPase Rap1 is important in mediating lymphocyte motility, and Rap1-GEFs are involved in...

Full description

Bibliographic Details
Main Authors: Sayaka Ishihara, Tsuyoshi Sato, Guangwei Du, Daniele Guardavaccaro, Akihiko Nakajima, Satoshi Sawai, Tohru Kataoka, Koko Katagiri
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Biology
Subjects:
Rap1
Lymphocyte trafficking
Chemokine
Migration
Online Access:http://link.springer.com/article/10.1186/s12915-020-00809-0

Internet

http://link.springer.com/article/10.1186/s12915-020-00809-0

Similar Items