Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress

Celastrol activates caspase-3/GSDME-dependent pyroptosis in tumor cells by inducing endoplasmic reticulum stress

Objective: To investigate the pyroptosis-inducing effects of celastrol on tumor cells and to explore the potential mechanisms involved, specifically focusing on the role of the caspase-3/gasdermin E (GSDME) signaling pathway and the impact of endoplasmic reticulum (ER) stress and autophagy. Methods:...

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Bibliographic Details
Main Authors: Jiajian Guo, Dongxiao Cui, Yuping Tang, Sanjiao Wang, Cuiyan Ma, Wenfu Ma
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Journal of Traditional Chinese Medical Sciences
Subjects:
Celastrol
Tumor cells
Pyroptosis
GSDME
Caspase-3
Endoplasmic reticulum stress stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2095754824000346

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http://www.sciencedirect.com/science/article/pii/S2095754824000346

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