Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by debilitating heterotopic ossification (HO). The retinoic acid receptor gamma agonist, palovarotene, and antibody-mediated activin A blockade have entered human clinical trials, but how these therapeutic modalitie...

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Bibliographic Details
Main Authors: John B Lees-Shepard, Sarah-Anne E Nicholas, Sean J Stoessel, Parvathi M Devarakonda, Michael J Schneider, Masakazu Yamamoto, David J Goldhamer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Series:eLife
Subjects:
fibrodysplasia ossificans progressiva
palovarotene
fibro/adipogenic progenitor
heterotopic ossification
activin A
ACVR1
Online Access:https://elifesciences.org/articles/40814

Internet

https://elifesciences.org/articles/40814

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