Photoreceptor-induced RPE phagolysosomal maturation defects in Stargardt-like Maculopathy (STGD3)

Abstract For many neurodegenerative disorders, expression of a pathological protein by one cell type impedes function of other cell types, which in turn contributes to the death of the first cell type. In transgenic mice modelling Stargardt-like (STGD3) maculopathy, human mutant ELOVL4 expression by...

Full description

Bibliographic Details
Main Authors: Camille Dejos, Sharee Kuny, Woo Hyun Han, Heather Capel, Hélène Lemieux, Yves Sauvé
Format: Article
Language:English
Published: Nature Portfolio 2018-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-24357-4