Microglia-specific transcriptional repression of interferon-regulated genes after prolonged stress in mice

Microglia-specific transcriptional repression of interferon-regulated genes after prolonged stress in mice

Stress-induced neuroinflammation is considered an important mechanism in the pathogenesis of depression. As immune effector cells in the brain, microglia play an essential role in neuroinflammation under stress, but the underlying mechanism remains controversial. Here, we performed RNA-seq and ATAC-...

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Bibliographic Details
Main Authors: Yuan Zhang, Yuhao Dong, Yueyan Zhu, Daijing Sun, Shunying Wang, Jie Weng, Yue Zhu, Wenzhu Peng, Bo Yu, Yan Jiang
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Neurobiology of Stress
Subjects:
Chronic stress
Interferon signaling
Microglia
Transcriptome
Chromatin accessibility
Activating transcription factor 3
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289522000704

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http://www.sciencedirect.com/science/article/pii/S2352289522000704

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