Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque.

Selective inhibition of PI3K/Akt/mTOR signaling pathway regulates autophagy of macrophage and vulnerability of atherosclerotic plaque.

Macrophage infiltration contributes to the instability of atherosclerotic plaques. In the present study, we investigated whether selective inhibition of PI3K/Akt/mTOR signaling pathway can enhance the stability of atherosclerotic plaques by activation of macrophage autophagy. In vitro study, selecti...

Full description

Bibliographic Details
Main Authors: Chungang Zhai, Jing Cheng, Haroon Mujahid, Hefeng Wang, Jing Kong, Yue Yin, Jifu Li, Yun Zhang, Xiaoping Ji, Wenqiang Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090563&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090563&type=printable

Similar Items