Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase

Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase

PrimPols are a class of primases that belong to the archaeo-eukaryotic primase (AEP) superfamily but have both primase and DNA polymerase activities. Replicative polymerase from NrS-1 phage (NrSPol) is a representative of the PrimPols. In this study, we identified key residues for the catalytic acti...

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Bibliographic Details
Main Authors: Fengtao Huang, Xueling Lu, Chunxiao Yu, Piotr Sliz, Longfei Wang, Bin Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Microbiology
Subjects:
DNA polymerase
primase
DNA replication
de novo synthesis
phage
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.766612/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2021.766612/full

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