(<i>S</i>)-Pramipexole and Its Enantiomer, Dexpramipexole: A New Chemoenzymatic Synthesis and Crystallographic Investigation of Key Enantiomeric Intermediates

(<i>S</i>)-Pramipexole and Its Enantiomer, Dexpramipexole: A New Chemoenzymatic Synthesis and Crystallographic Investigation of Key Enantiomeric Intermediates

A new chemoenzymatic method has been developed for the synthesis of (<i>S</i>)- and (<i>R</i>)-<i>N</i>-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl) acetamide, two key synthons for the preparation of (<i>S</i>)-pramipexole, an anti-Parkinson drug...

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Bibliographic Details
Main Authors: Samuele Ciceri, Patrizia Ferraboschi, Paride Grisenti, Shahrzad Reza Elahi, Carlo Castellano, Matteo Mori, Fiorella Meneghetti
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Catalysts
Subjects:
chiral synthons
pramipexole
dexpramipexole
Parkinson’s disease
hypereosinophilic syndromes
biocatalysis
Online Access:https://www.mdpi.com/2073-4344/10/8/941

Internet

https://www.mdpi.com/2073-4344/10/8/941

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