(<i>S</i>)-Pramipexole and Its Enantiomer, Dexpramipexole: A New Chemoenzymatic Synthesis and Crystallographic Investigation of Key Enantiomeric Intermediates
A new chemoenzymatic method has been developed for the synthesis of (<i>S</i>)- and (<i>R</i>)-<i>N</i>-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl) acetamide, two key synthons for the preparation of (<i>S</i>)-pramipexole, an anti-Parkinson drug...
Main Authors: | Samuele Ciceri, Patrizia Ferraboschi, Paride Grisenti, Shahrzad Reza Elahi, Carlo Castellano, Matteo Mori, Fiorella Meneghetti |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-08-01
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Series: | Catalysts |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4344/10/8/941 |
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