Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma

Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma

Quantitative differences in signal transduction are to date an understudied feature of tumour heterogeneity. The MAPK Erk pathway, which is activated in a large proportion of human tumours, is a prototypic example of distinct cell fates being driven by signal intensity. We have used primary hepatocy...

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Bibliographic Details
Main Authors: Anthony Lozano, Francois-Régis Souche, Carine Chavey, Valérie Dardalhon, Christel Ramirez, Serena Vegna, Guillaume Desandre, Anaïs Riviere, Amal Zine El Aabidine, Philippe Fort, Leila Akkari, Urszula Hibner, Damien Grégoire
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
oncogenic dosage
tumour heterogeneity
microenvironment
NK cells
liver
Online Access:https://elifesciences.org/articles/76294

Internet

https://elifesciences.org/articles/76294

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