Chemical Genetic Validation of CSNK2 Substrates Using an Inhibitor-Resistant Mutant in Combination with Triple SILAC Quantitative Phosphoproteomics

Chemical Genetic Validation of CSNK2 Substrates Using an Inhibitor-Resistant Mutant in Combination with Triple SILAC Quantitative Phosphoproteomics

Casein Kinase 2 (CSNK2) is an extremely pleiotropic, ubiquitously expressed protein kinase involved in the regulation of numerous key biological processes. Mapping the CSNK2-dependent phosphoproteome is necessary for better characterization of its fundamental role in cellular signalling. While ATP-c...

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Bibliographic Details
Main Authors: Laszlo Gyenis, Daniel Menyhart, Edward S. Cruise, Kristina Jurcic, Scott E. Roffey, Darren B. Chai, Flaviu Trifoi, Sam R. Fess, Paul J. Desormeaux, Teresa Núñez de Villavicencio Díaz, Adam J. Rabalski, Stephanie A. Zukowski, Jacob P. Turowec, Paula Pittock, Gilles Lajoie, David W. Litchfield
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein kinase CK2
CSNK2
chemical genetics
CX-4945
phosphoproteomics
SILAC
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.909711/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.909711/full

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