CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells

CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells

ABSTRACTDuring HIV infection of CD4+ T cells, ubiquitin pathways are essential to viral replication and host innate immune response; however, the role of specific E3 ubiquitin ligases is not well understood. Proteomics analyses identified 116 single-subunit E3 ubiquitin ligases expressed in activate...

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Bibliographic Details
Main Authors: Ujjwal Rathore, Paige Haas, Vigneshwari Easwar Kumar, Joseph Hiatt, Kelsey M. Haas, Mehdi Bouhaddou, Danielle L. Swaney, Erica Stevenson, Lorena Zuliani-Alvarez, Michael J. McGregor, Autumn Turner-Groth, Charles Ochieng' Olwal, Yaw Bediako, Hannes Braberg, Margaret Soucheray, Melanie Ott, Manon Eckhardt, Judd F. Hultquist, Alexander Marson, Robyn M. Kaake, Nevan J. Krogan
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:mBio
Subjects:
human immunodeficiency virus
ubiquitin E3 ligases
HIV latency
CRISPR screen
resting primary T cells
Online Access:https://journals.asm.org/doi/10.1128/mbio.02222-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02222-23

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