Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M. tuberculosis knockout strain for cdd gene was obtained by allelic replacement. Evaluatio...

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Bibliographic Details
Main Authors: Anne Drumond Villela, Valnês S Rodrigues-Junior, Antônio Frederico Michel Pinto, Virgínia Carla de Almeida Falcão, Zilpa Adriana Sánchez-Quitian, Paula Eichler, Cristiano Valim Bizarro, Luiz Augusto Basso, Diógenes Santiago Santos
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ)
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Mycobacterium tuberculosis
cdd gene
cytidine deaminase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100785&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017001100785&lng=en&tlng=en

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