Adaptation of a human gut epithelial model in relation to the assessment of clinical pharmacokinetic parameters for selected tyrosine kinase inhibitors

Adaptation of a human gut epithelial model in relation to the assessment of clinical pharmacokinetic parameters for selected tyrosine kinase inhibitors

The absorption, efflux and transport properties of two of the most commonly used tyrosine kinase inhibitors (TKIs), Erlotinib (E) and Gefitinib (G) were investigated using an adapted workable methodology of a 3-day Caco-2 cell monolayer transwell system, a standard model to test drug permeability an...

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Bibliographic Details
Main Authors: Richard Honeywell, Christien Fatmawati, Marita Buddha, Sarina Hitzerd, Ietje Kathman, Godefridus Peters
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2015-03-01
Series:ADMET and DMPK
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/169

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http://pub.iapchem.org/ojs/index.php/admet/article/view/169

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