Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression

Interference with megalin expression/endocytic function by montelukast mitigates gentamicin nephrotoxicity: Downregulation of ClC-5 expression

Megalin receptor-mediated endocytosis participates a crucial role in gentamicin (GM) uptake, accumulation, and toxicity. In this study, we investigated the potential effects of montelukast (MLK) on megalin expression/endocytic function against GM nephrotoxicity. Male Wistar rats were administered GM...

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Bibliographic Details
Main Authors: Amany A. Azouz, Dina A. Hanna, Ali A. Abo-Saif, Basim Anwar Shehata Messiha
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Saudi Pharmaceutical Journal
Subjects:
Gentamicin endocytosis
Megalin
Chloride channel-5
Montelukast
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016421002620

Internet

http://www.sciencedirect.com/science/article/pii/S1319016421002620

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