Regulatory T-cell deficiency leads to features of autoimmune liver disease overlap syndrome in scurfy mice

Regulatory T-cell deficiency leads to features of autoimmune liver disease overlap syndrome in scurfy mice

IntroductionScurfy mice have a complete deficiency of functional regulatory T cells (Treg) due to a frameshift mutation in the Foxp3 gene. The impaired immune homeostasis results in a lethal lymphoproliferative disorder affecting multiple organs, including the liver. The autoimmune pathology in scur...

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Bibliographic Details
Main Authors: Kaan Yilmaz, Stefanie Haeberle, Yong Ook Kim, Marvin J. Fritzler, Shih-Yen Weng, Benjamin Goeppert, Verena K. Raker, Kerstin Steinbrink, Detlef Schuppan, Alexander Enk, Eva N. Hadaschik
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
Treg
scurfy mice
autoimmune liver disease
overlap syndrome
primary biliary cholangitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253649/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1253649/full

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