Validated DBS method for filgotinib quantitation in rat dried blood spots and its application to a pharmacokinetic study in rats

Validated DBS method for filgotinib quantitation in rat dried blood spots and its application to a pharmacokinetic study in rats

Filgotinib is a selective JAK1 (Janus kinase) inhibitor, showed efficacy in patients suffering from moderate-to-severe rheumatoid arthritis. In this paper, we present the data on the development and validation of a sensitive, selective and high-throughput LC-MS/MS (liquid chromatography with tandem...

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Bibliographic Details
Main Authors: Abhishek Dixit, Vinay Kiran, Bhavesh Babulal Gabani, Ramesh Mullangi
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2020-06-01
Series:ADMET and DMPK
Subjects:
filgotinib
lc-ms/ms
method validation
rat blood
dbs
pharmacokinetics
Online Access:http://pub.iapchem.org/ojs/index.php/admet/article/view/796

Internet

http://pub.iapchem.org/ojs/index.php/admet/article/view/796

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