A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy
Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and enduring disorder caused by several anti-neoplastic agents. CIPN typically presents w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-08-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fnins.2017.00481/full |
| _version_ | 1818318584310398976 |
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| author | Yusuke Fukuda Yusuke Fukuda Yihang Li Yihang Li Rosalind A. Segal Rosalind A. Segal |
| author_facet | Yusuke Fukuda Yusuke Fukuda Yihang Li Yihang Li Rosalind A. Segal Rosalind A. Segal |
| author_sort | Yusuke Fukuda |
| collection | DOAJ |
| description | Chemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and enduring disorder caused by several anti-neoplastic agents. CIPN typically presents with neuropathic pain, numbness of distal extremities, and/or oversensitivity to thermal or mechanical stimuli. This adverse side effect often requires a reduction in chemotherapy dosage or even discontinuation of treatment. Currently there are no effective treatment options for CIPN. While the underlying mechanisms for CIPN are not understood, current data identify a “dying back” axon degeneration of distal nerve endings as the major pathology in this disorder. Therefore, mechanistic understanding of axon degeneration will provide insights into the pathway and molecular players responsible for CIPN. Here, we review recent findings that expand our understanding of the pathogenesis of CIPN and discuss pathways that may be shared with the axonal degeneration that occurs during developmental axon pruning and during injury-induced Wallerian degeneration. These mechanistic insights provide new avenues for development of therapies to prevent or treat CIPN. |
| first_indexed | 2024-12-13T09:55:32Z |
| format | Article |
| id | doaj.art-a69d0abdcb644feb9e2a08d5078f9a6a |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T09:55:32Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-a69d0abdcb644feb9e2a08d5078f9a6a2022-12-21T23:51:47ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2017-08-011110.3389/fnins.2017.00481282486A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral NeuropathyYusuke Fukuda0Yusuke Fukuda1Yihang Li2Yihang Li3Rosalind A. Segal4Rosalind A. Segal5Department of Neurobiology, Harvard Medical SchoolBoston, MA, United StatesDepartment of Cancer Biology, Dana-Farber Cancer InstituteBoston, MA, United StatesDepartment of Neurobiology, Harvard Medical SchoolBoston, MA, United StatesDepartment of Cancer Biology, Dana-Farber Cancer InstituteBoston, MA, United StatesDepartment of Neurobiology, Harvard Medical SchoolBoston, MA, United StatesDepartment of Cancer Biology, Dana-Farber Cancer InstituteBoston, MA, United StatesChemotherapeutic agents cause many short and long term toxic side effects to peripheral nervous system (PNS) that drastically alter quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and enduring disorder caused by several anti-neoplastic agents. CIPN typically presents with neuropathic pain, numbness of distal extremities, and/or oversensitivity to thermal or mechanical stimuli. This adverse side effect often requires a reduction in chemotherapy dosage or even discontinuation of treatment. Currently there are no effective treatment options for CIPN. While the underlying mechanisms for CIPN are not understood, current data identify a “dying back” axon degeneration of distal nerve endings as the major pathology in this disorder. Therefore, mechanistic understanding of axon degeneration will provide insights into the pathway and molecular players responsible for CIPN. Here, we review recent findings that expand our understanding of the pathogenesis of CIPN and discuss pathways that may be shared with the axonal degeneration that occurs during developmental axon pruning and during injury-induced Wallerian degeneration. These mechanistic insights provide new avenues for development of therapies to prevent or treat CIPN.http://journal.frontiersin.org/article/10.3389/fnins.2017.00481/fullaxonchemotherapyCIPNdegenerationDRGneuropathy |
| spellingShingle | Yusuke Fukuda Yusuke Fukuda Yihang Li Yihang Li Rosalind A. Segal Rosalind A. Segal A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy Frontiers in Neuroscience axon chemotherapy CIPN degeneration DRG neuropathy |
| title | A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy |
| title_full | A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy |
| title_fullStr | A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy |
| title_full_unstemmed | A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy |
| title_short | A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy |
| title_sort | mechanistic understanding of axon degeneration in chemotherapy induced peripheral neuropathy |
| topic | axon chemotherapy CIPN degeneration DRG neuropathy |
| url | http://journal.frontiersin.org/article/10.3389/fnins.2017.00481/full |
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