XLF acts as a flexible connector during non-homologous end joining

XLF acts as a flexible connector during non-homologous end joining

Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks in vertebrates. During NHEJ DNA ends are held together by a multi-protein synaptic complex until they are ligated. Here, we use Xenopus laevis egg extract to investigate the role of the intrinsically d...

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Bibliographic Details
Main Authors: Sean M Carney, Andrew T Moreno, Sadie C Piatt, Metztli Cisneros-Aguirre, Felicia Wednesday Lopezcolorado, Jeremy M Stark, Joseph J Loparo
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
DNA repair
non-homologous end joining
DNA double strand break
single-molecule FRET
Online Access:https://elifesciences.org/articles/61920

Internet

https://elifesciences.org/articles/61920

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