Improvement of Kiteplatin Efficacy by a Benzoato Pt(IV) Prodrug Suitable for Oral Administration

Improvement of Kiteplatin Efficacy by a Benzoato Pt(IV) Prodrug Suitable for Oral Administration

Kiteplatin, [PtCl<sub>2</sub>(<i>cis</i>-1,4-DACH)] (DACH = diaminocyclohexane), contains an isomeric form of the oxaliplatin diamine ligand <i>trans</i>-1<i>R</i>,2<i>R</i>-DACH and has been proposed as a valuable drug candidate against ci...

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Bibliographic Details
Main Authors: Alessandra Barbanente, Valentina Gandin, Cecilia Ceresa, Cristina Marzano, Nicoletta Ditaranto, James D. Hoeschele, Giovanni Natile, Fabio Arnesano, Concetta Pacifico, Francesco P. Intini, Nicola Margiotta
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
cisplatin
oxaliplatin
kiteplatin
antitumor drugs
oral administration
colorectal cancer
Online Access:https://www.mdpi.com/1422-0067/23/13/7081

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https://www.mdpi.com/1422-0067/23/13/7081

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