Physicochemical properties, pharmacokinetic studies, DFT approach, and antioxidant activity of nitro and chloro indolinone derivatives

Physicochemical properties, pharmacokinetic studies, DFT approach, and antioxidant activity of nitro and chloro indolinone derivatives

The process of developing of new drugs is greatly hampered by their inadequate physicochemical, pharmacokinetic, and intrinsic characteristics. In this regard, the selected chloro indolinone, (Z)-6-chloro-3-(2-chlorobenzylidene)indolin-2-one (C1), and nitro indolinone, (Z)-6-chloro-3-(2-nitrobenzyli...

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Bibliographic Details
Main Authors: Abdul Saboor Pirzada, Haroon Khan, Waqas Alam, Hany W. Darwish, Ahmed A. Elhenawy, Aleksey Kuznetsov, Maria Daglia
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Chemistry
Subjects:
indolinone derivatives
ADME study
density function theory study
antioxidant assays
therapeutic potential
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1360719/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2024.1360719/full

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