Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway

Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway

ObjectiveTo investigate the effects and mechanism of hyperinsulinemia on the metabolic switch to β‐hydroxybutyrate (BHB) absorption and utilization under a starvation or hypoxic environment in proximal tubular epithelial cells.MethodsA high-fat diet-induced hyperinsulinemia model in ZDF rats was use...

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Bibliographic Details
Main Authors: Jinlan Xie, Feifei Zhong, Zhenhong Guo, Xinran Li, Jingyu Wang, Zhongai Gao, Baocheng Chang, Juhong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Endocrinology
Subjects:
Hyperinsulinemia
metabolic flexibility
proximal tubular epithelial cells
mitochondria
β-hydroxybutyrate
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.960835/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.960835/full

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