Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups.

Polymorphic variation in TIRAP is not associated with susceptibility to childhood TB but may determine susceptibility to TBM in some ethnic groups.

Host recognition of mycobacterial surface molecules occurs through toll like receptors (TLR) 2 and 6. The adaptor protein TIRAP mediates down stream signalling of TLR2 and 4, and polymorphisms in the TIRAP gene (TIRAP) have been associated with susceptibility and resistance to tuberculosis (TB) in a...

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Bibliographic Details
Main Authors: Shobana Rebecca Dissanayeke, Samuel Levin, Sandra Pienaar, Kathryn Wood, Brian Eley, David Beatty, Howard Henderson, Suzanne Anderson, Michael Levin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2724706?pdf=render

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http://europepmc.org/articles/PMC2724706?pdf=render

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