CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells

CREB Is Activated by the SCF/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells

cAMP response element binding protein (CREB) functions as a prototypical stimulus-inducible transcription factor (TF) that initiates multiple cellular changes in response to activation. Despite pronounced expression in mast cells (MCs), CREB function is surprisingly ill-defined in the lineage. Skin...

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Bibliographic Details
Main Authors: Kristin Franke, Gürkan Bal, Zhuoran Li, Torsten Zuberbier, Magda Babina
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
mast cells
skin
CREB
SCF
KIT
ERK1/2
Online Access:https://www.mdpi.com/1422-0067/24/4/4135

Internet

https://www.mdpi.com/1422-0067/24/4/4135

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