BML-111 inhibit H2O2-induced pyroptosis and osteogenic dysfunction of human periodontal ligament fibroblasts by activating the Nrf2/HO-1 pathway

Abstract Background Periodontitis is a common and harmful chronic inflammatory oral disease, characterized by the destruction of periodontal soft and hard tissues. The NLRP3 inflammasome-related pyroptosis and human periodontal ligament fibroblasts (hPDLFs) osteogenic dysfunction are involved in its...

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Bibliographic Details
Main Authors: Yao Xu, Yi Chu, Wanrong Yang, Kefei Chu, Sihui Li, Ling Guo
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Oral Health
Subjects:
Online Access:https://doi.org/10.1186/s12903-023-03827-w