Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment

Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment

The incorporation of siRNA into nanocarriers is mandatory to facilitate its intracellular delivery, as siRNA itself cannot enter cells. However, the incorporation of these nanocarriers into oral, solid dosage forms and their fate in the gastrointestinal environment is yet to be explored. In the pres...

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Bibliographic Details
Main Authors: Asad Ur Rehman, Virginie Busignies, Marcela Coelho Silva Ribeiro, Nayara Almeida Lage, Pierre Tchoreloff, Virginie Escriou, Christine Charrueau
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceutics
Subjects:
oral delivery
RNA interference
solid dosage form
gel electrophoresis
nanocarriers
Online Access:https://www.mdpi.com/1999-4923/13/11/1807

Internet

https://www.mdpi.com/1999-4923/13/11/1807

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