High-fat diets enhance and delay ursodeoxycholic acid absorption but elevate circulating hydrophobic bile salts

High-fat diets enhance and delay ursodeoxycholic acid absorption but elevate circulating hydrophobic bile salts

Background: Ursodeoxycholic acid (UDCA) is a natural drug essential for the treatment of cholestatic liver diseases. The food effects on the absorption of UDCA and the disposition of circulating bile salts remain unclear despite its widespread global uses. This study aims to investigate the effects...

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Bibliographic Details
Main Authors: Liang Huang, Wei Wei, Xiaomei Huang, Xuejing Li, Haisha Liu, Lanlan Gui, Jinping Jiang, Linfei Wan, Xiangxiang Zhou, Jingsong Ding, Xuehua Jiang, Bikui Zhang, Ke Lan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
ursodeoxycholic acid
food effect
pharmacokinetics
glycoursodeoxycholic acid
bile salts
bile acids
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1168144/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1168144/full

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