In vitro versus in vivo models of kidney fibrosis: Time-course experimental design is crucial to avoid misinterpretations of gene expression data

In vitro versus in vivo models of kidney fibrosis: Time-course experimental design is crucial to avoid misinterpretations of gene expression data

Background: In vitro models are common tools in nephrology research. However, their validity has rarely been scrutinized. Materials and Methods: Considering the critical role of transforming growth factor (TGF)-β and hypoxia pathways in kidney fibrosis, kidney-derived cells were exposed to TGF-β and...

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Bibliographic Details
Main Authors: Shiva Moein, Kobra Moradzadeh, Shaghayegh Haghjooy Javanmard, Seyed Mahdi Nasiri, Yousof Gheisari
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Journal of Research in Medical Sciences
Subjects:
chronic kidney failure
hypoxia pathway
rhythmic behavior
transforming growth factor-β pathway
time-course analysis
Online Access:http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=84;epage=84;aulast=Moein

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http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2020;volume=25;issue=1;spage=84;epage=84;aulast=Moein

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