Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer

Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer

Previous work utilizing proteomic and immunohistochemical analyses has identified that high levels of acid ceramidase (AC) expression confers a poorer response to neoadjuvant treatment in locally advanced rectal cancer. We aimed to assess the radiosensitising effect of biological and pharmacological...

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Bibliographic Details
Main Authors: Rachael E. Clifford, Naren Govindarajah, David Bowden, Paul Sutton, Mark Glenn, Mahnaz Darvish-Damavandi, Simon Buczacki, Ultan McDermott, Zdzislaw Szulc, Besim Ogretmen, Jason L. Parsons, Dale Vimalachandran
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
acid ceramidase
ionizing radiation
LCL521
rectal cancer
Online Access:https://www.mdpi.com/2073-4409/9/12/2693

Internet

https://www.mdpi.com/2073-4409/9/12/2693

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