PET Imaging of the Adenosine A<sub>2A</sub> Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [<sup>18</sup>F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy

PET Imaging of the Adenosine A<sub>2A</sub> Receptor in the Rotenone-Based Mouse Model of Parkinson’s Disease with [<sup>18</sup>F]FESCH Synthesized by a Simplified Two-Step One-Pot Radiolabeling Strategy

The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) is regarded as a particularly appropriate target for non-dopaminergic treatment of Parkinson’s disease (PD). An increased A<sub>2A</sub>R availability has been found in the human striatum at early stages of P...

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Bibliographic Details
Main Authors: Susann Schröder, Thu Hang Lai, Magali Toussaint, Mathias Kranz, Alexandra Chovsepian, Qi Shang, Sladjana Dukić-Stefanović, Winnie Deuther-Conrad, Rodrigo Teodoro, Barbara Wenzel, Rareş-Petru Moldovan, Francisco Pan-Montojo, Peter Brust
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
adenosine A<sub>2A</sub> receptor
Parkinson’s disease
rotenone-based mouse model
PET imaging
[<sup>18</sup>F]<b>FESCH</b>
two-step one-pot radiosynthesis
Online Access:https://www.mdpi.com/1420-3049/25/7/1633

Internet

https://www.mdpi.com/1420-3049/25/7/1633

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