Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells

Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells

Mast cells are implicated as detrimental players in inflammatory lung diseases, particularly asthma. Mast cells respond to activating stimuli by releasing a wide panel of pro-inflammatory compounds that can contribute profoundly to the pathology, and there is currently an unmet need for strategies t...

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Bibliographic Details
Main Authors: Aida Paivandy, Martin Sandelin, Helena Igelström, Per Landelius, Christer Janson, Fabio R. Melo, Gunnar Pejler
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
apoptosis
lysosomotropic agents
mast cells
granules
mefloquine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01645/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01645/full

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