The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

The intrinsically disordered protein TgIST from Toxoplasma gondii inhibits STAT1 signaling by blocking cofactor recruitment

Intrinsically disordered proteins (IDP) are pleotropic proteins with diverse functions. Here the authors show that an IDP, TgIST, from T. gondii blocks interferon-induced gene expression by binding to the STAT1 dimer interface and preventing the recruitment of co-transcriptional activators, CBP/p300...

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Bibliographic Details
Main Authors: Zhou Huang, Hejun Liu, Jay Nix, Rui Xu, Catherine R. Knoverek, Gregory R. Bowman, Gaya K. Amarasinghe, L. David Sibley
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31720-7

Internet

https://doi.org/10.1038/s41467-022-31720-7

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