Inactivation of Yes-Associated Protein Mediates Trophoblast Dysfunction: A New Mechanism of Pregnancy Loss Associated with Anti-Phospholipid Antibodies?

Inactivation of Yes-Associated Protein Mediates Trophoblast Dysfunction: A New Mechanism of Pregnancy Loss Associated with Anti-Phospholipid Antibodies?

Pregnancy morbidity induced by anti-phospholipid antibodies (aPL+/PM+) is mainly thought to arise from placental abnormalities. We attempted to investigate the effect of aPL on the activity of Yes-associated protein (YAP) in the trophoblast and how YAP regulated human trophoblasts function. Thus, HT...

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Bibliographic Details
Main Authors: Zengshu Huang, Zhijing Tang, Haiyun Guan, Wingting Leung, Lu Wang, Hexia Xia, Wei Zhang
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomedicines
Subjects:
antiphospholipid antibody
trophoblast
Yes-associated protein
cell biological function
progesterone
Online Access:https://www.mdpi.com/2227-9059/10/12/3296

Internet

https://www.mdpi.com/2227-9059/10/12/3296

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