Partial hepatectomy in rats results in immediate down-regulation of p27Kip1 in residual liver tissue by transcriptional and post-translational processes

Partial hepatectomy in rats results in immediate down-regulation of p27Kip1 in residual liver tissue by transcriptional and post-translational processes

Purpose: The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 may be involved in regulating re-entry of residual hepatocytes into the cell cycle upon loss of liver tissue by partial hepatectomy (PH). As yet, changes in Kip1 expression during the initial period following PH are not well characterized...

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Bibliographic Details
Main Authors: Anne-Katrin eRohlfing, Karoline eTrescher, Juliane eHähnel, Christian eMüller, Jan-Peter eHildebrandt
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Physiology
Subjects:
Cell Proliferation
Liver Regeneration
cyclin-dependent kinase inhibitor
Compensatory growth
cell cycle regulator
Kip1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00139/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00139/full

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