Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection

Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection

An effective therapeutic vaccine for the treatment of chronic hepatitis C virus (HCV) infection, as an adjunct to newly developed directly-acting antivirals (DAA), or for the prevention of reinfection, would significantly reduce the global burden of disease associated with chronic HCV infection. A r...

Full description

Bibliographic Details
Main Authors: Leo Swadling, John Halliday, Christabel Kelly, Anthony Brown, Stefania Capone, M. Azim Ansari, David Bonsall, Rachel Richardson, Felicity Hartnell, Jane Collier, Virginia Ammendola, Mariarosaria Del Sorbo, Annette Von Delft, Cinzia Traboni, Adrian V. S. Hill, Stefano Colloca, Alfredo Nicosia, Riccardo Cortese, Paul Klenerman, Antonella Folgori, Eleanor Barnes
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Vaccines
Subjects:
therapeutic vaccination
adenovirus
modified vaccinia Ankara
immunotherapy
HCV
T-cells
exhaustion
Online Access:http://www.mdpi.com/2076-393X/4/3/27

Internet

http://www.mdpi.com/2076-393X/4/3/27

Similar Items