Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy menResearch in context

Effect of high-dose glucocorticoid treatment on human brown adipose tissue activity: a randomised, double-blinded, placebo-controlled cross-over trial in healthy menResearch in context

Summary: Background: Glucocorticoids (GCs) are widely applied anti-inflammatory drugs that are associated with adverse metabolic effects including insulin resistance and weight gain. Previous research indicates that GCs may negatively impact brown adipose tissue (BAT) activity in rodents and humans...

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Bibliographic Details
Main Authors: Claudia Irene Maushart, Wenfei Sun, Alaa Othman, Adhideb Ghosh, Jaël Rut Senn, Jonas Gabriel William Fischer, Philipp Madoerin, Rahel Catherina Loeliger, Robyn Melanie Benz, Martin Takes, Christoph Johannes Zech, Alin Chirindel, Felix Beuschlein, Martin Reincke, Damian Wild, Oliver Bieri, Nicola Zamboni, Christian Wolfrum, Matthias Johannes Betz
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:EBioMedicine
Subjects:
Brown adipose tissue
Cold-induced thermogenesis
Glucocorticoids
Prednisone
Energy expenditure
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423003377

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http://www.sciencedirect.com/science/article/pii/S2352396423003377

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