Increased Collagen Crosslinking in Stiff Clubfoot Tissue: Implications for the Improvement of Therapeutic Strategies

Increased Collagen Crosslinking in Stiff Clubfoot Tissue: Implications for the Improvement of Therapeutic Strategies

Congenital clubfoot is a complex musculoskeletal deformity, in which a stiff, contracted tissue forms in the medial part of the foot. Fibrotic changes are associated with increased collagen deposition and lysyl oxidase (LOX)-mediated crosslinking, which impair collagen degradation and increase the t...

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Bibliographic Details
Main Authors: Jarmila Knitlova, Martina Doubkova, Adam Eckhardt, Martin Ostadal, Jana Musilkova, Lucie Bacakova, Tomas Novotny
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
relapsed clubfoot
congenital idiopathic <i>Talipes equinovarus</i>
collagen
contraction
crosslinking
beta-aminopropionitrile (BAPN)
Online Access:https://www.mdpi.com/1422-0067/22/21/11903

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https://www.mdpi.com/1422-0067/22/21/11903

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