Indoleamine 2,3-dioxygenase 1 promotes osteosarcoma progression by regulating tumor-derived exosomal miRNA hsa-miR-23a-3p

Indoleamine 2,3-dioxygenase 1 promotes osteosarcoma progression by regulating tumor-derived exosomal miRNA hsa-miR-23a-3p

Background: Osteosarcoma (OS) is the most common primary malignant tumor originating in bone. Immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1) participates in tumor immune tolerance and promotes tumor progression, while the study of IDO1 in OS is limited.Methods: Immunohistochemistry an...

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Bibliographic Details
Main Authors: Dan Yang, Yinxian Chen, Zhen Ning Tony He, Yichen Wang, Chenghui Ke, Yi Luo, Sun Wang, Qichao Ma, Mengjie Chen, Qing Yang, Ziming Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
osteosarcoma
indoleamine 2,3-dioxygenase 1
exosome miRNAs
tumor immunity
immunotherapeutic target
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1194094/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1194094/full

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