Adipose-Derived Stem Cells (ADSCs) Supplemented with Hepatocyte Growth Factor (HGF) Attenuate Hepatic Stellate Cell Activation and Liver Fibrosis by Inhibiting the TGF-β/Smad Signaling Pathway in Chemical-Induced Liver Fibrosis Associated with Diabetes

Adipose-Derived Stem Cells (ADSCs) Supplemented with Hepatocyte Growth Factor (HGF) Attenuate Hepatic Stellate Cell Activation and Liver Fibrosis by Inhibiting the TGF-β/Smad Signaling Pathway in Chemical-Induced Liver Fibrosis Associated with Diabetes

Liver fibrosis can develop on the background of hyperglycemia in diabetes mellitus. However, xenobiotic-related factors may accelerate diabetes-associated liver fibrosis. In this study, we aimed to assess the antfibrotic effect of ADSC and HGF therapy and to establish the cellular and molecular mech...

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Bibliographic Details
Main Authors: Sami Gharbia, Simona-Rebeca Nazarie, Sorina Dinescu, Cornel Balta, Hildegard Herman, Victor Eduard Peteu, Mihaela Gherghiceanu, Anca Hermenean, Marieta Costache
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cells
Subjects:
liver fibrosis
diabetes mellitus
adipose-derived stem cells
hepatocyte growth factor
hepatic stellate cells
TGF-β/Smad pathway
Online Access:https://www.mdpi.com/2073-4409/11/21/3338

Internet

https://www.mdpi.com/2073-4409/11/21/3338

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