Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesterol

PCSK9 negatively regulates low-density lipoprotein receptor (LDLR) abundance on the cell surface, leading to decreased hepatic clearance of LDL particles and increased levels of plasma cholesterol. We previously identified SURF4 as a cargo receptor that facilitates PCSK9 secretion in HEK293T cells (...

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Bibliographic Details
Main Authors: Vi T Tang, Joseph McCormick, Bolin Xu, Yawei Wang, Huan Fang, Xiao Wang, David Siemieniak, Rami Khoriaty, Brian T Emmer, Xiao-Wei Chen, David Ginsburg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
secretion
SURF4
PCSK9
APOB
cholesterol
Online Access:https://elifesciences.org/articles/82269

Internet

https://elifesciences.org/articles/82269

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